Deluzio scored 16 points in the first half, including a pair of 3-point baskets that spurred a 9-0 run late in the half and sent the Seminoles to the locker room with a 34-26 lead. She was 6 of 10 from the floor, including 4 of 7 from 3-point range.
Chelsea Davis added 12 points and seven rebounds in 20 minutes off the bench for the Seminoles (23-6, 11-3), who will play Friday night in the ACC tournament after an opening bye.
Clemson (10-19, 3-10) jumped out to an 8-2 lead but faltered quickly on its way to a sixth straight defeat. Kirstyn Wright and Sthefany Thomas each scored 11 points for the Tigers.
Clemson shot just 30 percent in the game, with 6-4 center Lindsey Mason going 0 for 10.
Florida State opened a 17-point early in the second half at 48-31 on a Natasha Howard free throw, but Clemson clawed back to within seven at 50-43 on Wright’s 3-point shot with 11:38 left before Howard’s layup recharged the winners.
The Seminoles missed out on a share of the ACC regular-season championship for the third straight year when Miami clinched at least part of the title with a win Sunday at Georgia Tech. Duke can also claim part of the championship with a win later Sunday over North Carolina.
The Seminoles have gone 35-7 in league play over the past three seasons.
Senior Christian Hunnicutt sat out her final home game with a sprained left knee and was replaced in the Florida State starting lineup by Chasity Clayton. It was the first time this season that coach Sue Semrau did not have her starting unit intact.
Semrau is hopeful that Hunnicutt will be ready for Florida State’s tournament opener Friday.
Bravard’s 15 points left her two shy of the 1,000 point career plateau.